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Oxidative stress plays a prominent role in SARS-CoV-2 infection following recognition of the viral S-protein by angiotensin converting enzyme-2 receptor and pattern recognition receptors like toll-like receptors 2 and 4, and activation of transcription factors like nuclear factor kappa B, that subsequently activate nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) expression succeeded by ROS production

Alcohol disrupts protein synthesis while tobacco compromises circulation and oxygen delivery to healing tissues

At 4 weeks, the weight, volume, and retention rate of the grafts were lower in the control group than those in the treatment group

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