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A primary cardiovascular end-point event occurred in 569 of the 8803 patients (6.5%) in the semaglutide group and in 701 of the 8801 patients (8.0%) in the placebo group (hazard ratio, 0.80

The baseline criteria are consistent across most CVS Caremark plans: BMI 30 or higher, OR BMI 27 or higher with at least one weight-related comorbidity (hypertension, type 2 diabetes, dyslipidemia, obstructive sleep apnea) Documented failure of a supervised diet and exercise program for at least 3 to 6 months No contraindications (personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2) But here's the part that trips up most patients: even if you meet every clinical criterion, your specific employer-sponsored plan may exclude coverage for weight-loss medications entirely

doi: 10.1007/s40265-014-0321-6 183 ChalasaniNYounossiZLavineJECharltonMCusiKRinellaMet al

Therefore, we recommend recording your progress, identifying trends, and adjusting your strategy as needed

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HbA1c typically rises after discontinuation, with the magnitude depending on baseline diabetes severity, duration of disease, and alternative therapies implemented