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Add it to the water phase and keep processing temperatures below 40 C (104F)

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Notably, LASSS displayed additional functions to promote receptor binding-affinity and nitration resistance of HGF in a dose-dependent manner, that is high-dose LASSS in excess of a 1:4000 molar ratio to HGF, as revealed by biochemical assays after wash-out of un-reacted free LASSS (Figure 2a-d)

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Compared to Matrixyl 3000, GHK-Cu produced a 31.6% reduction in wrinkle volume