Incidence of severe hypoglycemia was 1% b Hypoglycemia was more frequent when RYBELSUS was used in combination with insulin secretagogues (eg, sulfonylurea) or insulin - Patients may require a lower dose of the secretagogue or insulin to reduce the risk of hypoglycemia in this setting A cardiovascular outcomes trial (CVOT) compared RYBELSUS added to standard of care vs placebo added to standard of care Primary endpoint was the time to first occurrence of a 3-part composite outcome of major adverse cardiovascular events (MACE), which included cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke The total number of primary component MACE endpoints was 137 (61 [3.8%] with RYBELSUS and 76 [4.8%] with placebo) CV=cardiovascular
To view or add a comment, sign in A recent cohort study (not an RCT) found that semaglutide decreased the risk of psychiatric illness
[Ca 2+ ] i imaging videos were analysed using the Fiji imaging processing package
GLP-1 medications in the context of Hashimoto disease require careful thyroid monitoring, because the metabolic effects of suboptimal thyroid function can completely neutralize the caloric deficit that GLP-1 therapy creates
Gastroenterology 127 , 546558 (2004)
Your pharmacist can advise whether any interactions suggest separating your GLP-1 injection from other treatments