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Bioavailability advantages favor l-citrulline for sustained nitric oxide support, while l-arginine's direct mechanisms benefit immediate-response applications

Gaytan et al., 2003

The mouse model used for these experiments is a general knockout and we can therefore discount the possibility that GLP-1 exerts its inhibitory action by paracrine effects secondary to activation of GLP-1Rs in delta and beta cells, suggesting that GLP-1s glucagonostatic effect involves a receptor distinct from GLP-1R

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Future research should focus on large-scale, well-controlled randomized trials with standardized dosing protocols, clearly defined deficiency thresholds, and long-term follow-up to strengthen the evidence base and guide clinical practice