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Out of the 36 metabolic pathways that showed significant changes in metabolic activity in response to the GDH2 gene deletion when cells were cultured in MM medium, all except phosphonate and phosphinate metabolism were upregulated (Fig

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Safety assessments in both rodent and nonhuman primate studies reveal a favorable profile: neurobehavioral testing indicates no deficits in motor or cognitive function, and systemic pharmacokinetic analyses show minimal doxorubicin leakage into the circulation (166, 168)

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