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Slow gut transit time produced by hypothyroidism, dehydration, low dietary fibre, or vagal nerve dysfunction allows Candida populations to establish biofilm colonies in the colon

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Moreover, glucocorticoids act on almost all types of immune cells and perform salient immunosuppressive and anti-inflammatory functions through genomic and non-genomic mechanisms [190]

Supporting this mechanism, studies in animal models demonstrate that L-carnitine administration increases the expression of mitochondrial superoxide dismutase-2 (SOD2), reduces markers of inflammation, and alleviates overall oxidative burden (63)

Other Precautions: Long-term use may reduce zinc levels