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PWS is a sleep state sharing many features with REM/Paradoxical Sleep, including pontine activation, ponto-midbrain-telencephalic wave propagation, rostro-caudal voluntary muscle atonia propagation, heart beat and breathing arrhythmia as well as wake-like activity of the telencephalon (Leung et al

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The injection site reactions are more prominent than GLP-1s but not treatment-limiting for most people