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Likewise, lactate-administered mito147 cell-bearing mice exhibited significantly recovered primary tumor growth, facilitated lung metastasis (Figs

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However, considering that the human bodys endogenous antioxidant system is not sufficient, the human body can hardly produce nonenzymatic antioxidants, so it depends on exogenous nonenzymatic antioxidants, such as mineral elements, nutritional antioxidants, phytochemicals, cytoprotectants and synthetic compounds (Table 1) [34, 36]

Collectively, these features indicate that ferroptosis is intrinsically predisposed to propagation because its execution chemistry, membrane-based substrate, and threshold-dependent defense systems all favor nonlinear amplification

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