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This decline may be due to the decreased GLP-1 secretion or impairment of L-cell development [15,16,17,18]

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From a metabolic standpoint, GLP-1 analogs improve glucose regulation and reduce insulin spikes, especially in individuals with insulin resistance

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Additionally, Fe2+ binds to the N-terminal domain of A, destabilizing its helical structure and promoting peptide aggregation by enhancing peptide-peptide interactions (37)