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When GLP-1 medication is stopped, several changes occur: appetite returns, food becomes more noticeable again, the volume of the food noise starts to increase and the sense of control that felt easy during treatment can start to slip away
204 Mazdutide, a dual GLP-1/glucagon RA, and retatrutide, a triple GLP-1/GIP/glucagon RA, also have both shown significant weight loss effects in Phase 2 trials
The most common AEs recorded following administration of PF-06882961 were nausea, vomiting, and decreased appetite, all of which were considered treatment-related by the investigator and consistent with the expected effects of the GLP-1R agonist mechanism
They stand up to any scientific scrutiny
