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Research shows that blocking NNMT in fat tissue leads to higher energy expenditure 1

By numbing the skin at the injection site first with ice or topical creams, then you reduce some the bruising and soreness that come with weekly or monthly vitamin B12 injections

However, there are a few downsides to consider: Invasive: Receiving regular injections may be uncomfortable for some people, as it requires visiting a clinic or performing self-injections

Always check the expiry date on the product packaging and use before it

Any of these make an auto-immune cause of B12 deficiency (PA, also called autoimmune gastritis 3 ) more likely

Reconstitution does not apply to oral capsules