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Under these conditions, the increased secretion of counterregulatory hormones stimulates FFAs oxidation in the liver and accelerates the production of ketone bodies, which are metabolized in muscle, adipose tissue and, most importantly, in heart and brain ( As demonstrated in a recent meta-analysis, SGLT-2i treatment is associated with increased plasma fasting glucagon levels in patients with diabetes compared with non-SGLT-2i treatments with a reduction of insulin and increased ketone body levels (91)
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Less Frequent Dosing: Instead of a daily pill, injections are typically given on a weekly or monthly schedule as determined by a healthcare provider
The active ingredient is the same, the mechanism of action is identical, and expected weight loss results are equivalent
Furthermore, GLP-1 enhances energy utilization, optimizing cardiac metabolism [44]
