Studies showed that the levels of total carnitine, free carnitine, L-carnitine and C3:0 in dialysis patients were lower than those in healthy controls, while those of C4:0, isoamyl C4:0 and C18:1-OH were higher
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In breast cancer models, a single low dose of MedTAC (PTK7) induces profound and sustained protein degradation, leading to marked tumor control and prolonged survival without systemic toxicity [71]
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The findings closed the loop, linking a metabolite and its transporter to metastasis by demonstrating that mitochondrial glutathione import via the SLC25A39 transporter is essential for cancer spread