Acronyms CrCl - Creatinine clearance GLP-1 - Glucagon-Like Peptide-1 P - Drugs with pediatric dosing Dulaglutide Trulicity Trulicity Dosage forms Single-dose pen 0.75 mg/0.5 ml 1.5 mg/0.5 ml 3 mg/0.5 ml 4.5 mg/0.5 ml Comes in carton with 4 pens Dosing Type 2 diabetes Starting: 0.75 mg once weekly Maintenance: 0.75 - 4.5 mg once weekly Max: 4.5 mg once weekly Increase to next higher dose if needed at intervals of 4 weeks May administer without regard to food If a dose is missed, administer ASAP if there are at least 3 days until the next scheduled dose If less than 3 days remain before the next scheduled dose, skip the missed dose and administer the next dose on the regularly scheduled day In each case, patients can then resume their regular once weekly dosing schedule The day of weekly administration can be changed if necessary as long as the last dose was administered 3 or more days before Kidney disease No dose adjustment is recommended in patients with renal impairment including end-stage renal disease Gastrointestinal side effects may be worse in patients with kidney disease Liver disease In a study of patients with varying degrees of liver disease, no clinically relevant change in dulaglutide pharmacokinetics was observed

Women of childbearing potential should use effective contraception while on treatment and discuss stopping the medication before planned conception
Abdominal pain may manifest in different forms such as dull pain, bloating, or cramping, and its mechanism of occurrence may be related to the effect of drugs on gastrointestinal smooth muscle
The HPRA is the Irish Competent Authority responsible for cosmetics, medicines, and medical devices, and as such, it is in charge of post-market surveillance
It also protects the skin from oxidative stress, boosts skin health, and promotes a clearer complexion
The study surveyed about 60,000 patients who were at least 66 years old and were taking GLP-1s to treat type 2 diabetes or heart disease