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IF also activates the nuclear factor erythroid 2related factor 2 (Nrf2) pathway, a master regulator of antioxidant response, leading to the upregulation of superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) [38]

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Pregnancy and breastfeeding warrant avoidance due to insufficient safety data in these populations

Agarwal R, Filippatos G, Pitt B, Anker SD, Rossing P, Joseph A, et al

See Supplementary Note for rationale of using U46C GPX4

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