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Treatment usually begins with 2.5 mg once weekly , followed by gradual titration in 2.5 mg increments every few weeks to minimize gastrointestinal side effects such as nausea , vomiting , or diarrhea

In contrast, a more recent study in HFD+STZ-induced type 2 diabetic mice used intravitreal lentiviral vectors to modulate apelin expression and reported that apelin overexpression (LV-Apelin + ) preserved pericyte density, reduced vascular leakage, and upregulated tight junction proteins ZO-1 and occludin, whereas apelin knockdown aggravated pericyte loss and leakage (149)

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Many people benefit from being more deliberate about fluids, especially during dose increases when nausea or reduced appetite can drive intake down

Hormone Replacement Therapy (HRT) If your weight gain is driven by menopause or Low-T, no amount of dieting will fix it

Khaity, A