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In GIPR, Q138 1.40b and two glutamic acid residues (E135 1.37b and E288 45.52b ) make three hydrogen bonds with Y10 P and T7 P , while F22 P and MeL13 P /L14 P in retatrutide interact with Y36 ECD and R131 1.33b through stacking and hydrophobic contacts, respectively
Dulaglutide (Trulicity, Eli Lilly) consists of two fused GLP-1 analogues, with a glycine substitution at position 2, a glutamic acid substitution at position 20 and a glycine at position 30, which protect against DPP-IV degradation [19, 32]