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Genetics play a role in metabolic response, though the specific genetic variants influencing body composition during GLP-1 agonist treatment remain under investigation
They demonstrated that losing weight may have a greater impact on androgens compared to improving glycemic control, particularly in the groups with liraglutide and dulaglutide, and with dapaglifozin ( Although in healthy subjects the acute effect of GLP-1 infusion has led to contradictory results ( Studies using a high-fat diet (HFD) induced obesity mice model characterized by decreased serum T levels, impaired sperm quality, and increased testis inflammation, showed that exenatide administration was able to reduce body weight and improve the quality of sperm without increasing serum T levels but lowering the expression of proinflammatory cytokines ( Overall, these data support the use of GLP1-RAs in functional hypogonadism in the context of obesity or T2DM
Common Questions About Injecting Semaglutide Q1: Can I inject semaglutide anywhere on my body
Boxhammer E et al
Patients may notice initial energy improvements within the first few sessions, while hair, skin, and nail benefits typically become noticeable after 46 weeks of consistent treatment
GLP-1 receptor agonists (like semaglutide) and tirzepatide already show benefits in NAFLD/NASH
