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By delivering glutathione directly into the bloodstream or muscle tissue, patients may achieve faster absorption compared to oral supplements

Without this final addition, the compound cannot function as a complete antioxidant

NAC has been used clinically for decades as an FDA-approved drug for acetaminophen overdose (where it replenishes hepatic glutathione) and as a mucolytic agent [18]

Here both supplements are generally discouraged

While glutathione is generally considered well-tolerated, some individuals may experience: Discomfort at the injection site Digestive changes such as bloating or cramping Headaches or temporary fatigue Rare allergic reactions Excessively high doses, especially when administered too frequently, may interfere with natural antioxidant regulation

doi:10.3945/ajcn.114.091819