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Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease

This discovery, reported in Cell Metabolism , challenged the traditional view of mitochondria solely as power generators and introduced the concept of bidirectional mitochondrial-nuclear communication

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Prolonged exposure of platelets to elevated glucose concentrations can result in alterations to platelet mitochondrial function, including heightened oxygen consumption and an increase in mitochondrial membrane potential, 427 causing excessive production of ROS, and exacerbates platelet activation

However, no cases of hypoglycemia were reported in phase 2 trials

Schrder H, Marrugat J, Vila J, Covas MI, Elosua R