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The emergence of GIP receptor (GIPR)GLP1 receptor (GLP1R) co-agonists has fostered growing interest in the actions of GIP and GLP1 in metabolically relevant tissues

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Preclinical models indicate that GLP-1 receptor activation can influence the gut-brain axis as well as the hypothalamic-pituitary-adrenal (HPA) axis, with possible implications for stress regulation and energy homeostasis[11]

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