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Myocardial expression of somatotropic axis, adrenergic signalling, and calcium handling genes in heart failure with preserved ejection fraction and heart failure with reduced ejection fraction

Whilst GLP-1 receptor agonists do not typically cause increased urination as a primary adverse effect, patients may experience urinary changes for several reasons related to their treatment journey

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Improvement of liver enzymes was explained by the direct action of GLP-1RAs on GLP-1 receptors located on the hepatocyte that enhances weight loss, insulin sensitivity, hepatic fat oxidation, reduces denovo lipogenesis, hepatic steatosis, and alleviates oxidative stress [27,28,29,30,31,32,33,34]

Medicare will allow coverage for Wegovy when prescribed for the cardiovascular indication

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