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Results Overall structure The tirzepatideGIPRG s , tirzepatideGLP-1RG s , peptide 20GIPRG s , peptide 20GLP-1RG s and peptide 20GCGRG s structures were determined by the single-particle cryo-EM approach with overall resolutions of 3.4 , 3.4 , 3.1 , 3.0 , and 3.5 , respectively (Fig