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When introduced into cell cultures or tissue models, the compound triggers intracellular cyclic AMP (cAMP) generation and activates downstream kinase cascades
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Cpi-613 rewires lipid metabolism to enhance pancreatic cancer apoptosis via the ampk-acc signaling
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Intestinal proglucagon cleaves (breaks up) into several different molecules: GLP-1 GLP-2 GRPP Oxyntomodulin The enzyme PCSK1 converts proglucagon to GLP-1 in the central nervous system
Among animal models, laser-induced IOP elevation in primates is arguably the most physiologically relevant
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