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The evolution of loss of heterozygosity on chromosome 17 during the progression to Barretts adenocarcinoma involves a unique combination of target sites in individual specimens

Science 347 , 13741377 (2015)

The excess AGEs could lead to non-enzymatic cross-linking of collagen, break the adhesion of osteoblasts to the extracellular matrix and leads to bone fragility ( / mice are mainly used to study atherosclerosis, but ApoE / mice can also be used to study osteoporosis

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Sample analysis for polar metabolites was carried out by MS-Omics as follows

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