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The main culprits include: Ultraviolet and visible light exposure the strongest daily stimulator Hormonal fluctuations (pregnancy, contraceptives, thyroid changes) Inflammation from acne, eczema or injury (post-inflammatory hyperpigmentation) Ageing and genetics Certain medications or skin trauma Globally, pigmentary disorders affect a significant portion of the population, with surveys showing around half of adults reporting at least one pigmentation concern
Dextran sulfate sodium colitis study Wild-type mice (812 weeks of age) were allowed ad libitum access to drinking water containing 1.5%2% dextran sulfate sodium (DSS, MW = 36,00050,000
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