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This study uncovers the significant role of peroxisomes-ether phospholipid axis in modulating susceptibility and evasion of iron dependent death, emphasizing that PUFA-ePLs represent a unique functional lipid category that is dynamically regulated during cellular state transitions, suggesting multiple regulatory nodes as potential therapeutic targets for diseases involving iron dependent death (Zou et al., 2020a)

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Cell 172 , 409422 e421 (2018)

WATCHLIST Medicines and health innovations for which expanded access could provide significant health benefits but for which supporting data are lacking and/or key challenges need to be addressed for expanded access through MPP licensing to lead to public health impact