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Safety Outcomes Nausea, constipation, vomiting, diarrhea, and eructation were the most common adverse events reported with orforglipron, and these gastrointestinal events occurred more frequently with orforglipron than with placebo (Table 3 and Fig

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When estrogen walks out the door, it impacts musculoskeletal tissue, including muscle, bone, fat, and muscle-derived stem cells, because those all have estrogen receptors, she says