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doi: 10.1208/s12248-025-01018-9 179 ZhangSLiuJOuyangXLiuWWangYZhongJ

It has been found that a high-glucose environment reduces the expression levels of Sirt1 and Nrf2 in the nuclei of retinal pigment epithelial cells and inhibits the expression of downstream Nrf2 genes such as GPX4, GCLC, and GCLM (190)

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NAD+s role in cellular repair has also made it a popular experimental therapy for improved health in aging, with the idea that maintaining higher NAD+ might support healthy aging processes