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However, this pathway is reported to be inactive in most tissues, and in the few tissues in which it is active, its function is reduced in tumours from the corresponding tissue 16

Edited by Professor Alessandro Finazzi-Agr Supplementary information Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made

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