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So the practical takeaway is not oral is better or SC is better. It is: pick one route, follow the documented per-dose figure for the vial you have, and keep the route constant so that whatever you observe is not confounded by a mid-stream route change

In other words, toxicity from B12 is extremely rare

Vegetarians, vegans, and older adults may be more prone to its deficiency

One small human study found that 7 out of 12 patients with chronic knee pain reported meaningful relief lasting six months or more after a single injection

It has been studied specifically in Achilles tendon, rotator cuff, patellar tendon, and other tendon injury models

Its primary function is to transfer a methyl group to nicotinamide, a form of vitamin B3