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They can advise based on their specific formulation stability profile

(b) a low serum concentration of vitamin B12 with a normal folate concentration

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Freeze-thaw cycling is the specific mechanism most likely to degrade HCG after it reaches you, and it is entirely under your control: a single reconstitution split into pre-planned aliquots exposes the material once, while repeatedly warming and refreezing one container exposes it as many times as you open it

But too much or too little of a particular nutrient can sometimes cause problems

Example: Vitamin D improves calcium absorption