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However, this method has also a disadvantage such as high production costs of (R)-4-chloro-3-hydroxybutyrate derivate, and a difficulty of application thereof to industrial-scale production in that the reaction must be carried out under high- temperature and high-pressure conditions
Berberine is not unstudied
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Poor storage can shorten the effective lifespan of the product
The BMI cutoff was chosen to best assess the primary endpoint (time in range, that is, glycemic control) through several hypothetical mechanisms of semaglutide, while reducing the risk of participants becoming underweight
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