Glutamate Supply and Metabolism in Infants
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Docetaxel-loaded solid lipid nanoparticles prevent tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells
higher levels of AGE receptors were noted in the 1,021 participants with dementia at the beginning of the study 295 Study 5 Study Design: Observational/Correlational Subjects: 764 adults Results: Skin AGE levels were correlated with poorer cognitive performance and the relationship was similar in those with and without diabetes 296 Confidence of Harmfulness: Low* Glutamate Description: An amino acid and excitatory neurotransmitter Potential Mechanism(s): Excitotoxicity triggering neuroinflammation, oxidative stress, protein aggregation, mitochondrial dysfunction, and nerve cell death 297,298 Scientific Evidence: Study 1 Study Design: Two placebo-controlled intervention trials Subjects: Veterans with Gulf War Illness Dose: A challenge dose of glutamate, in the form of monosodium glutamate (MSG), versus placebo after eating a low-glutamate diet for one month Results: Glutamate inconsistently caused return of symptoms, although symptoms, including cognitive impairment, were reduced after the low-glutamate diet 299,300 Study 2 Study Design: RCT Subjects: 159 dementia patients Dose: 900 mg glutamate in the form of MSG three times daily versus placebo Results: Dementia scores improved in those receiving glutamate 301 Study 3 Study Design: Two research reviews Results: No compelling evidence for glutamate sensitivity as a cause of cognitive or other symptoms in otherwise healthy individuals 302,303 Confidence of Harmfulness: Low* RCT = Randomized controlled trial *High = supportive evidence from multiple randomized controlled trials (RCTs) and observational studies
Whether L-carnitine aids weight loss
[PMID: 18607224] PubMed record related to this compound for laboratory literature review
