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Promotes weight loss by reducing hunger and enhancing fat breakdown
Ex-4 also promotes brain-derived insulin production and enhances insulin signaling through the Wnt/-catenin/NeuroD1 signaling pathway, which subsequently reduces tau hyperphosphorylation and cognitive dysfunction in diabetic mice [64]
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SS31 (elamipretide) is a mitochondriatargeted tetrapeptide that selectively binds cardiolipin in the inner mitochondrial membrane [1] , stabilizing electron transport chain complexes and reducing reactive oxygen species production while enhancing ATP synthesis [2]
This dual action, increasing fat breakdown while blocking fat formation, creates a metabolic environment that favors net fat loss even when caloric intake is not dramatically reduced
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