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are inventors on a patent application covering GLP-1 analogues described here
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Researchers from University of Oxford, University of Dundee, University of Copenhagen, University of British Columbia, Churchill Hospital, Newcastle University, University of Bath and University of Exeter also contributed to the work
Our study provided valuable evidence for selecting appropriate GLP-1 RAs to avoid the occurrence of GLP-1 RA-induced gastrointestinal AEs
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This observation underscores a recurring challenge in developing functional antibodies against GIPR: high-affinity binding does not always translate into improved antagonistic potency, possibly due to the complex conformational dynamics of the receptor or the necessity of precisely occluding the orthosteric peptide-binding site
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