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This direct delivery raises plasma concentrations within minutes, which is why IV remains the preferred route for therapeutic outcomes

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Opportunities exist for a few, more broadly used backbone agents to emerge which play across several market segments, as monotherapies and as part of combination approaches

Glutathione supplementation is a low-risk, mechanistically plausible intervention worth testing

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J Pharmacol Exp Ther 285: 608618 ChenZ,PuttDA,LashLH (2000) Enrichment and functional reconstitution of glutathione transport activity from rabbit kidney mitochondria: further evidence for the role of the dicarboxylate and 2oxoglutarate carriers in mitochondrial glutathione transport