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Administration of GLP-1 and exendin-4 promoted neurite outgrowth in cultured dorsal root ganglion (DRG) neurons, presumably explaining the increased nerve fibers observed in biopsies of IBS individuals [51]

doi: 10.1126/science.270.5240.1326 95 BobustucGCKassamABRovinRAJeudySSmithJSIsleyBet al

3numerous confluent changes): (a) the hemorrhagic zone, (b) edema, (c) the loss of neurons in anterior horn and intermediate gray matter, (d) vacuoles, and (e) the loss of lateral and posterior spinal column tracts

VEGFR2, VEGF receptor 2

This receptor has been implicated in DNA repair and antioxidant pathways, raising the possibility that melanocortin signaling contributes to cell survival mechanisms

Reduced Glucagon Secretion: Semaglutide GLP-1 decreases glucagon release, a hormone that raises blood sugar, thus preventing unnecessary glucose release from the liver