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This is highly relevant as PKA-RI aggregates undergo LLPS to form biomolecular condensates 65 which spatially restrict PKA activity, leading to signal compartmentalisation 25 , explaining why the direct presence of endosomal GLP-1R at ERMCSs is required to assemble this signalling hub, and uncovering a new modality of GLP-1R signal transduction which involves the local assembly of a biomolecular condensate containing not only signalling mediators such as SPHKAP/PKA, and also presumably adenylate cyclase, but also downstream targets for PKA phosphorylation such as the MICOS complex and other ERMCS components, some likely found amongst the active GLP-1R interactors identified in our interactome analysis

& Mikuteit, M

Lean protein at every meal is the single most important dietary priority on GLP-1 medications Cooked vegetables are easier to tolerate than raw ones, especially early in treatment Nutrient density matters more than volume when your appetite is reduced PEAKs dietitian creates personalized meal plans that account for your medication, preferences, and goals When you start a GLP-1 medication like Wegovy, Zepbound, Foundayo, or Ozempic, your appetite changes significantly

Popovic M, Warr DG, Deangelis C, Tsao M, Chan KK, Poon M, Yip C, Pulenzas N, Lam H, Zhang L, Chow E

589(Pt 4):963-73

Integration of multi-omics data facilitates a comprehensive system-level understanding of carcinogenesis and therapeutic vulnerabilities, which single-omics data fails to provide