difficile) Avoid colonoscopy in toxic megacolon Management Induction of remission: Mildmoderate: 5-ASA (oral rectal) Moderatesevere: Corticosteroids Severe/refractory: Biologics (anti-TNF, anti-integrin, JAK inhibitors) Maintenance: 5-ASA Azathioprine / biologics (if steroid-dependent) Complications Toxic megacolon Severe bleeding Perforation Colorectal cancer (risk with duration & extent) Surgical Indications Refractory disease Dysplasia or carcinoma Toxic megacolon Massive hemorrhage Colectomy is curative Continuous disease, rectum always involved Limited to mucosa Associated with PSC Smoking appears protective (opposite of Crohns) To view or add a comment, sign in Systemic Lupus Erythematosus (SLE) Definition: SLE is a chronic autoimmune disease in which the immune system attacks multiple organ systems, causing inflammation and tissue damage
Cardiovascular outcomes GLP-1 receptor agonists have demonstrated cardiovascular risk reduction in large outcome trials
GLP-1 stands for glucagon-like peptide-1 receptor agonist medications, usually administered in the form of a subcutaneous injection
Differential gene expression analysis For differential gene expression analysis, a pseudo-bulk count matrix was generated by summing the transcript counts for all cells within the same cell type and mouse identity combination
Many patients continue treatment through a maintenance phase to prevent weight regain and support metabolic health markers
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