With proper management, the long-term benefits of this treatment outweigh the temporary discomforts
Tirzepatide is the first approved dual GIP/GLP-1 receptor agonist, engineered from the native GIP peptide backbone with structural modifications enabling potent activation of both incretin receptors
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A cohort study found that GLP-1RAs were associated with a reduced risk of hepatic decompensation and mortality in individuals with type 2 diabetes cirrhosis (Yen et al., 2024)
Glucose metabolism via the PPP is essential for the generation of NADPH that is required for reductive biosynthetic reactions such as those of cholesterol biosynthesis, bile acid synthesis, steroid hormone biosynthesis, and fatty acid synthesis