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In a 4-year cardiovascular outcomes trial (Trial 7), cholelithiasis was reported in 1.1% of patients treated with RYBELSUS 14 mg and in 0.9% of placebo-treated patients
H.ElrahmanM
Typically, peptides the size of GLP-1 (~30 amino acids) have extremely low oral bioavailability unless helped by penetration enhancers or special formulations
This reduces the burden of daily medication management and enhances adherence to the treatment plan
In clinical trials it is given as a once-weekly subcutaneous injection
To overcome this challenge, oral semaglutide products such as Rybelsus and oral Wegovy use an absorption enhancer called SNAC (sodium N-[8-(2-hydroxybenzoyl) amino] caprylate)
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