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As expected, hepsin / mice displayed heightened oxidative stress after APAP exposure compared to wild-type mice, indicated by a significant decrease in GSH and an increase in nitrotyrosine levels, leading to more severe liver damage and mortality

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An increase in superoxide dismutase, glutathione peroxidase, and Nrf2 levels and decrease in thiobarbituric acid reactive substances were observed, attenuating oxidative stress

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Simplified Determination of Carboxyhemoglobin