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The only difference is the total amount of lyophilized peptide in the vial

Finally, the absence of validated biomarkers for predicting treatment response or monitoring efficacy further complicates both clinical research and practical application, limiting the ability to personalize therapy or objectively assess outcomes

Because the IOMs RDA is considerably lower than the EFSAs AI, we chose to provide a lower recommendation to meet the RDA and a higher recommendation to meet the EFSAs AI

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Treatment should start urgently and should not be delayed for laboratory confirmation if neurological features strongly suggest B12 deficiency

Author contributions MT and SG were responsible for the conceptualization