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Gastrointestinal (GI) side effects in patients, such as nausea, diarrhea, abdominal discomfort, or constipation, can occur with both drugs

Subtle conformational dynamics allow the C-terminus of GLP-1 to access the ECD binding site, and the ligand binding triggers further dissociation of the ECD from the TMD allowing the N-terminus of GLP-1 to enter the orthosteric pocket in the TMD and activate the receptor

Weight regain occurs in many patients who discontinue treatment without maintaining lifestyle modifications

(1999) demonstrated that topical and intraperitoneal application of Thymosin Beta-4 increased re-epithelialization by 42-61% over controls in a rat full-thickness wound model

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Healthcare providers can offer additional strategies including prescription medications, referral to gastroenterology if indicated, or consideration of alternative diabetes or weight management therapies if gastrointestinal side effects significantly impair quality of life