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Many patients choose injections to bypass digestion and ensure direct absorption
For skin-related concerns, doctors commonly recommend injections because they bypass digestive breakdown and provide higher bioavailability
Mikelsaar et al
Defend against oxidative stress 3
Long-term low B12 can drive elevated homocysteine and contribute to megaloblastic or pernicious anemia
The 2025 IV pilot measured cardiac, hepatic, renal, thyroid, and glucose biomarkers and reported no abnormalities (Lee et al., 2025), which gives a sense of what those investigators considered worth checking
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