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The dosing is gradually increased over time to reduce the chance of gastrointestinal discomfort, which is common during early weeks of treatment

Previous studies have shown that the control level of glycemia is positive with reduced incidence of microvascular diseases, such as diabetic kidney diseases and diabetic retinopathy, although it has a weak relationship with improvement of macrovascular diseases

In the STEP clinical trials, the proportion of people experiencing nausea dropped significantly after the first few months of treatment

The proliferative effect of DBZ can be amplified by SCFAs in small intestinal organoids, highlighting the benefits of combination therapies [198]

Efficacy and safety of saxagliptin in older participants in the SAVOR-TIMI 53 trial