Lele Wang, [email protected] These authors have contributed equally to this work and share first authorship These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
BRIN-BD11 cells were used throughout this study for their well characterised responses to multiple stimuli, cell culture based convenience and their established intact response to GLP-1R activation both in terms of cAMP and resulting stimulated insulin secretion 36, 37
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These changes underscore that tirzepatide produces pharmacological rather than curative effectsbenefits persist only with continued treatment
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