Common Side Effects of Tirzepatide and Semaglutide The most frequently reported side effects include: Nausea (particularly during dose increases) Diarrhea or constipation Vomiting Abdominal discomfort Decreased appetite (expected effect) Most side effects occur during dose escalation and typically improve within 4-8 weeks as your body adjusts to the medication
Doctor of Medicine BAMS, FMC, MD Resident Most side effects are temporary and generally harmless and resolve when discontinuing this medicine
The most common type, obstructive sleep apnea (OSA), happens when throat muscles relax excessively, causing airway blockages
Currently, in vitro studies on peptide-mediated DDIs, which would provide better in vitro to in vivo extrapolation, remain poorly established
Mallet et al., 2023
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